Specialty Physician Designed Treatment Program. A chemotherapy treatment package cost is estimated based on various factors including patient test results, required services and procedures for treatment. Doctors ultimately determine the depth of treatment needed, but it can be understood that the longer and more involved the treatment and the chemotherapeutic agents used affect the overall cost. Treatment cost includes the facility fee, physician's fee, cost of chemotherapy drugs and any related medical procedures required to administer the plan of care. Not included are diagnostic studies, consultations with additional specialists and cost of complication management; travel and lodging.